Skeletal development and osteoarthritis.
نویسندگان
چکیده
منابع مشابه
Skeletal development and osteoarthritis.
The limited ability of articular cartilage to repair after traumatic insult or during arthritic degeneration is widely attributed to the fact that the tissue lacks both innervation and vascularisation. However, comparative studies of articular cartilage repair in load bearing and non-load bearing areas of the joint, in addition to some in vitro studies suggest more strongly that adult articular...
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Osteoarthritis (OA), or degenerative joint disease, is the most common form of joint pathology, and it has an extensive history. Indeed, it has been observed in a variety of fossil animals, and has been reported in the fossil remains of dinosaurs.' Among preindustrial human groups, as documented by skeletal remains, osteoarthritic changes are quite frequently the most common pathological lesion...
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Parathyroid hormone-related protein (PTHrP) participates in the regulation of endochondral bone development. After the cartilage mold is established in fetal life, perichondrial cells and chondrocytes at the ends of the mold synthesize PTHrP. This ligand then acts on PTH/PTHrP receptors on chondrocytes. As chondrocytes go through a program of proliferation and then further differentiation into ...
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Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1994
ISSN: 0003-4967
DOI: 10.1136/ard.53.10.624